Development of Discriminating Dissolution Method for an Insoluble Drug: Nisoldipine
نویسندگان
چکیده
Nisoldipine is poorly soluble drug. There is no official dissolution method available in the literature or recommended by regulatory agencies. In present study dissolution method was developed. the media selection was done by solubility study of drug in different pH as well as in different surfactant solution. Volume of media was found by calculating sink condition. Sodium lauryl suphate, 1.0% was found to be most suitable surfactant. Further method selection at different rotation speed and volume of media and their discriminating power was evaluated using simple model independent approach. We observed that higher paddle speeds result to flattering drug release profiles and losses its discriminating power while at low paddle speed method was found to be more discriminating. Discriminating dissolution method for Nisoldipine is paddle at 60 rpm, 500 mL of 1.0% sodiul lauryl sulphate solution.
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